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Table 2 Medical history and disease characteristics

From: Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study

Characteristic

Early responders n = 332

Later responders n = 253

Patients without Halm-based assessment of TCS n = 1454

Relevant medical conditions at hospitalization (initial visit*) (≥ 5% of analysis population), n (%)

 Any relevant condition

255 (76.8)

210 (83.0)

1133 (77.9)

 Respiratory disease

108 (32.5)

90 (35.6)

491 (33.8)

 Diabetes

54 (16.3)

52 (20.6)

263 (18.1)

 Congestive heart disease

48 (14.5)

51 (20.2)

237 (16.3)

 Cancer/malignancy

30 (9.0)

27 (10.7)

180 (12.4)

 Peripheral vascular disease

34 (10.2)

23 (9.1)

126 (8.7)

 Renal disease

17 (5.1)

20 (7.9)

110 (7.6)

 Other relevant conditions

118 (35.5)

102 (40.3)

464 (31.9)

Age of patients with comorbidities, years, mean (SD) [median]

67.5 (17.2) [71]

66.3 (17.92) [72]

68.2 (16.4) [71]

Age of patients without comorbidities, years, mean (SD) [median]

51.9 (19.7) [49]

55.5 (17.0) [54]

52.4 (20.1) [50]

Medication history in the 3 months prior to hospitalization, n (%)

 Any prior medication

159 (47.5)

148 (58.5)

836 (57.5)

 Antibiotics/antivirals

51 (15.4)

52 (20.6)

292 (20.1)

 Anticoagulants

56 (16.9)

39 (15.4)

206 (14.2)

 Immunosuppressants/immunomodulators

19 (5.7)

19 (7.5)

113 (7.8)

 Non-steroidal anti-inflammatory drugs

23 (6.9)

16 (6.3)

98 (6.7)

 Any other relevant therapies*

58 (17.5)

47 (18.6)

274 (18.8)

 Unknown

8 (2.4)

18 (7.1)

120 (8.3)

  1. *Visit to hospital for current infection or date of diagnosis of infection for patients already hospitalized.
  2. As defined by the investigator.
  3. SD = standard deviation; TCS = time to clinical stability.