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Figure 8 | Respiratory Research

Figure 8

From: Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells

Figure 8

Assessment of fibrosis mechanisms in OSA + MSC vs Sham + S rats. (A) ACE, (B) MMP-2 and (C) IL-6 mRNA expression (ng-equ) in the four cardiac chambers of Sham + Saline (n = 7) and OSA + MSC (n = 8) rats (Mean ± SEM *P < 0.05). D. Plasmatic concentration (pg/mL) of IL-1β in Sham + Saline and OSA + MSC rats (Mean ± SEM *P < 0.05). E. MMP-2 protein levels quantification. Representative MMP-2 blots (upper panel), Ponceau-stained membranes (middle panel) and normalized quantification (lower panel) (Mean ± SEM). n = 4-6/group. Left lane is a molecular-weight marker lane; the picture was obtained with visible light. A.U.: Arbitrary Units.

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