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Figure 7 | Respiratory Research

Figure 7

From: Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

Figure 7

Depiction of in vitro experiments summarizing how ATO regulates TGF-β1 signaling. ATO blocks TGF-β1 induced fibroblast to myofibroblast differentiation by suppressing Smad2, Smad3 and Akt phosphorylation. ATO also blocks TGF-β1 induced NOX-4 mRNA expression and therefore abrogates TGF-β1-induced H2O2. Furthermore, ATO degrades PML bodies and suppresses PML protein expression, which regulates Smad3 phosphorylation and may play an important role in the pathogenesis of pulmonary fibrosis.

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