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Figure 5 | Respiratory Research

Figure 5

From: Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

Figure 5

Daily injection of ATO reduces PML body in C57BL/6 mouse lungs. (A) Bleomycin (2units/kg) and ATO (1 mg/kg) were administered to C57BL/6 mice (n = 7) as indicated. Bleomycin was administered by oropharyngeal aspiration. ATO was administered daily by intra-peritoneal injection. (B) Mice were sacrificed 14 days after bleomycin administration. Bleomycin induced PML body formation, while ATO disrupted their formation, in mouse lungs. (C) Densitometric quantification of PML body intensity for Figure 5B. *P value < 0.05, **P value <0.01, ***P value < 0.001.

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Respiratory Research

ISSN: 1465-993X

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