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Figure 6 | Respiratory Research

Figure 6

From: Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

Figure 6

Kinetic of the innate and adaptive responses induced by cigarette smoke exposure and the impact of smoking cessation. Resolution of the innate immune response (macrophages and neutrophils) measured in the BAL is markedly delayed when preceded by chronic exposure but can happen. Features of adaptive immune response (pulmonary TLT formation and elevated ANA) requires chronic exposure to be initiated but does not resolve following cessation. Moreover, the delay in the resolution of the innate immune response is associated with the activation of the adaptive immune response.

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