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Table 1 L. rhamnosus and budesonide treatment reduce the basal lung resistance in chronic asthmatic mice

From: Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma

Group Methacholine (mg/mL)
Basal 0 (saline) 0.38 0.75 1.56 3.13 6.25 12.5 25
  Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM
OVA/Sal-PBS 0.73 0.09 0.76 0.09 0.80 0.06 0.88 0.06 0.97 0.08 1.04 0.09 1.16 0.06 1.23 0.07 1.41 0.12
OVA/OVA-PBS 1.81# 0.31 1.79# 0.22 1.76# 0.19 1.85# 0.20 1.86# 0.21 1.82# 0.19 1.73# 0.15 1.96# 0.18 2.01# 0.21
OVA/Sal-B. breve 0.61 0.09 0.76 0.15 0.93 0.21 0.96 0.17 0.97 0.13 1.00 0.07 1.12 0.09 1.17 0.09 1.16 0.06
OVA/OVA-B. breve 1.74 0.58 1.66¤ 0.59 1.54 0.43 1.55 0.33 1.66 0.28 1.86 0.30 1.97 0.27 2.18 0.29 2.36 0.30
OVA/Sal-L. rhamnosus 0.64 0.09 0.73# 0.16 0.74 0.09 0.81 0.11 0.83 0.08 0.93 0.08 1.02 0.10 1.05 0.08 1.20 0.12
OVA/OVA-L. rhamnosus 1.05¤ 0.18 1.15¤ 0.14 1.13 0.13 1.18¤ 0.13 1.30¤ 0.12 1.48 0.13 1.55 0.14 1.69 0.16 1.80 0.16
OVA/Sal-BUD 0.55 0.02 0.56# 0.02 0.63 0.04 0.71 0.07 0.79 0.09 0.85 0.10 0.96 0.09 1.08 0.12 1.17 0.11
OVA/OVA-BUD 0.85¤ 0.12 0.88¤ 0.09 1.01¤ 0.09 1.10¤ 0.09 1.23¤ 0.13 1.38 0.13 1.57 0.15 1.73 0.10 1.80 0.16
  1. Airway response to saline and increasing doses of methacholine measured 24 h after the last OVA or saline challenge as expressed by lung resistance (LR). Basal airway response is also shown. Mice in all groups were sensitised to OVA. OVA/Sal mice were challenged with saline; OVA/OVA mice were challenged with OVA. Mice were treated with PBS (OVA/Sal-PBS; OVA/OVA-PBS), B. breve (OVA/Sal-B. breve; OVA/OVA-B. breve), L. rhamnosus (OVA/Sal-L. rhamnosus; OVA/OVA-L. rhamnosus) or budesonide (OVA/Sal-budesonide; OVA/OVA-budesonide). Results are shown as mean ± SEM, n = 6 mice/group. Statistical significance of differences was tested using post hoc Bonferroni’s multiple comparison test after one-way ANOVA. #Statistically significant difference (p < 0.05) compared to OVA/Sal-PBS mice. ¤Statistically significant difference (p < 0.05) compared to OVA/OVA-PBS mice. BUD = budesonide.