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Table 1 L. rhamnosus and budesonide treatment reduce the basal lung resistance in chronic asthmatic mice

From: Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma

Group

Methacholine (mg/mL)

Basal

0 (saline)

0.38

0.75

1.56

3.13

6.25

12.5

25

 

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

Mean

SEM

OVA/Sal-PBS

0.73

0.09

0.76

0.09

0.80

0.06

0.88

0.06

0.97

0.08

1.04

0.09

1.16

0.06

1.23

0.07

1.41

0.12

OVA/OVA-PBS

1.81#

0.31

1.79#

0.22

1.76#

0.19

1.85#

0.20

1.86#

0.21

1.82#

0.19

1.73#

0.15

1.96#

0.18

2.01#

0.21

OVA/Sal-B. breve

0.61

0.09

0.76

0.15

0.93

0.21

0.96

0.17

0.97

0.13

1.00

0.07

1.12

0.09

1.17

0.09

1.16

0.06

OVA/OVA-B. breve

1.74

0.58

1.66¤

0.59

1.54

0.43

1.55

0.33

1.66

0.28

1.86

0.30

1.97

0.27

2.18

0.29

2.36

0.30

OVA/Sal-L. rhamnosus

0.64

0.09

0.73#

0.16

0.74

0.09

0.81

0.11

0.83

0.08

0.93

0.08

1.02

0.10

1.05

0.08

1.20

0.12

OVA/OVA-L. rhamnosus

1.05¤

0.18

1.15¤

0.14

1.13

0.13

1.18¤

0.13

1.30¤

0.12

1.48

0.13

1.55

0.14

1.69

0.16

1.80

0.16

OVA/Sal-BUD

0.55

0.02

0.56#

0.02

0.63

0.04

0.71

0.07

0.79

0.09

0.85

0.10

0.96

0.09

1.08

0.12

1.17

0.11

OVA/OVA-BUD

0.85¤

0.12

0.88¤

0.09

1.01¤

0.09

1.10¤

0.09

1.23¤

0.13

1.38

0.13

1.57

0.15

1.73

0.10

1.80

0.16

  1. Airway response to saline and increasing doses of methacholine measured 24 h after the last OVA or saline challenge as expressed by lung resistance (LR). Basal airway response is also shown. Mice in all groups were sensitised to OVA. OVA/Sal mice were challenged with saline; OVA/OVA mice were challenged with OVA. Mice were treated with PBS (OVA/Sal-PBS; OVA/OVA-PBS), B. breve (OVA/Sal-B. breve; OVA/OVA-B. breve), L. rhamnosus (OVA/Sal-L. rhamnosus; OVA/OVA-L. rhamnosus) or budesonide (OVA/Sal-budesonide; OVA/OVA-budesonide). Results are shown as mean ± SEM, n = 6 mice/group. Statistical significance of differences was tested using post hoc Bonferroni’s multiple comparison test after one-way ANOVA. #Statistically significant difference (p < 0.05) compared to OVA/Sal-PBS mice. ¤Statistically significant difference (p < 0.05) compared to OVA/OVA-PBS mice. BUD = budesonide.
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Respiratory Research

ISSN: 1465-993X

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