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Table 1 Pulmonary function test of the ABCA3 AA patients and GA and GG carriers

From: A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant

  Homozygous AA Heterozygous GA Homozygous GG P
Patient A Patient B Patient C (n = 10) (n = 6)  
mean ± sd mean ± sd  
FVC (L) 2.01 2.60 4.09 2.91 ± 0.83 3.85 ± 0.66 0.0338
FVC (%) 52 68 88 95.86 ± 6.95 109.55 ± 24.68 0.1148
FEV1 (L/s) 1.82 1.95 3.18 2.34 ± 0.68 3.07 ± 0.62 0.0500
FEV1 (%) 54 65 86 97.19 ± 12.42 102.95 ± 19.02 0.4726
FEV1/VC 90.55 73.03 77.75 71.30 ± 6.66 70.45 ± 5.87 0.8004
FEV1/VC (%) 107 95 100 92.83 ± 11.47 87.55 ± 6.29 0.3209
  1. The family members carrying one A allele had a mean FVC absolute value slightly reduced compared to WT family members (p = 0.0338), but no difference when values were expressed as % predicted.