Inflammation and airspace enlargement after 24 weeks smoke exposure. A BAL total cells, mononuclear cells, and neutrophils at 24 weeks. B Average airspace area distributions by logarithmic bins of airspace size for 24 weeks, describing whole slice histology. C Average airspaces per unit area. D Average area to perimeter ratio produced from analysis of whole slice histology at 24. **p < 0.01 by two-tailed t-test compared to age-matched controls.