Impact of 24 weeks smoke exposure on lung function. A Representative axial CT (left) and log(V/Q) (right) images for control (top) and cigarette smoke exposed (bottom) animals after 24 weeks. Green represents matched V/Q while colours progressing towards purple and red represent increasing values of low and high V/Q, respectively. B Log(V/Q) distributions for animals at 24 weeks. C Average mean log(V/Q) values. D Average log(V/Q) standard deviation values. *p < 0.05, **p < 0.01 by two-tailed t-test compared to age-matched controls.