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Figure 3 | Respiratory Research

Figure 3

From: Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway

Figure 3

Hyperoxia-dependent inhibition of lung morphogenesis is attenuated by Vegf165 but not Vegf121. E11.5 lung explants exposed to (A) 3% oxygen (B) 50% oxygen (C) 50% oxygen + Vegf165 (50 ng/mL) or (D) 50% oxygen + Vegf121 (50 ng/mL ) for 2 d. (E) total number of terminal branches and (F) total branch length from lungs cultured as above were quantitated at E11.5 + 2. n = 4 per group, *p <0.05 vs. 3% alone and **p <0.05 vs. 50% alone and ***p <0.05 vs. 50% + Vegf165 at E11.5 + 2. Photographs at 4x magnification. Bar = 1 mm.

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