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Table 2 Cox regression of all-cause mortality in 2,249 patients on long-term oxygen therapy for COPD

From: Hypo- and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: a population-based prospective study

Parameter Hazard ratio 95% CI P-value
PaCO2 (air)† - - < 0.001
Age (per y) 1.04 1.03 – 1.05 < 0.001
Male 1.35 1.19 – 1.53 < 0.001
BMI    < 0.001*
  < 18.5 1.35 1.14 – 1.60 < 0.001
  18.5- 24.9 Ref - -
  25 - 29.9 0.73 0.60 – 0.88 0.001
  ≥ 30 0.80 0.64 – 1.00 0.051
WHO performance status    < 0.001*
  0 Ref - -
  1 1.01 0.74 – 1.39 0.927
  2 1.47 1.08 – 2.01 0.016
  3 2.26 1.62 – 3.16 < 0.001
  4 3.21 1.94 – 5.30 < 0.001
Missing 1.35 0.95 – 1.93 0.098
PaO2 (air) (per 1 kPa) 0.91 0.85 – 0.98 0.014
Cardiovascular diagnoses    < 0.001*
  0 Ref - -
  1 1.25 1.08 – 1.46 0.003
  2 1.42 1.20 – 1.68 < 0.001
  > 2 1.38 1.12 – 1.71 0.003
Oral glucocorticoids 1.16 1.02 – 1.31 < 0.001
Opioids 1.19 1.05 – 1.35 0.009
Benzodiazepines 1.18 1.03 – 1.34 0.014
  1. *Wald test of total significance for class variables with more than two categories.
  2. †The p-value is reported for both linear and squared term for PaCO2 (air).
  3. Abbreviations: CI, confidence interval; Ref, reference category.