Figure 3

Rosiglitazone and chloroquine and, but not isoproterenol and albuterol, can overcome increased contraction to methacholine. Airways in lung slices were pre-contracted with 100nM methacholine (MCh) or 300nM MCh, prior to 5 min perfusion with A) chloroquine (CQ, 100 μM, n = 4, 8), B) rosiglitazone (RGZ, 100 μM, n = 3, 4), C) isoproterenol (ISO, 10 μM, n = 3, 4) or D) albuterol (ALB, 10 μM, n = 4, 4). Responses (mean ± S.E.M) represent the average airway lumen area (normalized to the initial area), measured at 2 sec intervals over 5 min.