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Table 1 Clinical characteristics of the rapalogs induced interstitial pneumonitis

From: Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells

 

Medication

No. of cases

No. of interstitial pneumonitis (%)

Grade 3-4 (%)

Time to development (months)

Neoplastic disease

Everolimus

107

7 (6.5)

3 (2.8)

5.8

 

Temsirolimus

91

4 (4.4)

1 (1.1)

4.6

Solid organ transplantation

Rapamycin

107

5 (4.7)

3 (2.8)

8.6