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Table 1 Summary data describing study subjects undergoing sweat evaporimetry

From: Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease

   Healthy never smokers Healthy active smokers COPD active smokers COPD former smokers P Value Pairwise with P < 0.05
(ANOVA)
N   18 12 25 12   
Age (mean, SD)   47 ± 9 52 ± 8 58 ± 9 68 ± 8 < 0.001 HNS-CS, HNS-CFS, HS-CFS, CS-CFS
Gender N (%)        
  Male 11 (61%) 6 (50%) 19 (76%) 9 (75%) 0.387  
  Female 7 (39%) 6 (50%) 6 (24%) 3 (25%)   
Race N (%)        
  Caucasian 13 (72%) 4 (27%) 14 (56%) 8 (67%) 0.185  
  African-American 5 (28%) 8 (63%) 11 (44%) 4 (33%)   
Chronic bronchitis N (%) 0 (0%) 2 (18%) 13 (52%) 6 (50%) < 0.001 HNS-CS, HNS-CFS, HS-CS
Spirometry        
  FEV1 (L) (Mean, SD) 3.55 ± 1.02 2.92 ± 0.82 2.03 ± 0.73 1.23 ± 0.40 < 0.001 HNS-CS, HNS-CFS, HS-CS, HS-CFS, CS-CFS
  FEV 1 % pred (Mean, SD) 1.03 ± 0.10 0.97 ± 0.12 0.60 ± 0.16 0.41 ± 0.18 < 0.001 HNS-CS, HNS-CFS, HS-CS, HS-CFS, CS-CFS
Pack-years (Mean, SD) 0 31.08 ± 14 38 ± 19 44 ± 19 <0.0001 HNS-HS, HNS-CS, HNS-CFS
MMRC (Mean, SD)   0.06 ± .236 0.83 ± .577 1.96 ± 1.197 2.83 ± 1.03 < 0.001 HNS-HS, HNS-CS, HNS-CFS, HS-CS, HS-CFS, CS-CFS
BCSS (Mean, SD)   0.06 ± 0.236 0.75 ± 0.965 3.46 ± 3.007 2.67 ± 2.43 < 0.001 HNS-CS, HNS-CFS, HS-CS, HS-CFS
  1. MMRC = Modified Medical Research Council criteria; BCSS = Breathlessness, Cough and Sputum Scale. The mean and standard deviation for clinical characteristics for our patient cohorts are provided. Post-hoc pairwise analysis was done using least significant difference as appropriate. HNS = Healthy Never Smokers; HS = Healthy Smokers; CS = COPD Active Smokers; CFS = COPD Former Smokers.