Figure 2

Systemic CFTR dysfunction in COPD subjects as demonstrated by β-Adrenergic sweat secretion rate. (A) Representative sweat secretion assay tracings of a healthy never smoker (solid) and a COPD patient (dotted). Evaporative water loss is measured continuously following injection of (a¹) atropine, (c) carbachol, (a²) atropine again, and (b) β-adrenergic cocktail stimulus. The stable β-adrenergic stimulated sweat secretion rate is marked with a bar. (B) Summary data plotting maximal β-adrenergic sweat rate for each individual subject. *P < 0.05.