Table 2 Clinical characteristics of AECOPD at admission and outcomes
All patients | No Aspergillusspp. isolation | Aspergillusspp.isolation | p-value † | |
|---|---|---|---|---|
(n = 240) | (n = 120)# | (n = 24)# | ||
Heart rate, beats/min | 96.8 ± 16.1 | 94.7 ± 14.8 | 95.6 ± 13.4 | 0.624 |
Respiratory rate, breath/min | 23.3 ± 8.9 | 22.4 ± 9.7 | 24.7 ± 7.6 | 0.286 |
Body temperature, °C | 36.7 ± 0.9 | 36.4 ± 0.8 | 36.8 ± 0.9 | 0.574 |
Type of exacerbation £ | ||||
Type I | 110 (45.8) | 56 (46.6) | 10 (41.6) | 0.340 |
Type II | 59 (24.3) | 30 (25.0) | 5 (20.8) | 0.127 |
Type III | 81 (33.4) | 34 (28.3) | 9 (37.5) | 0.193 |
Laboratory findings | ||||
Leucocytes, x 109/L | 11.8 ± 6.3 | 11.2 ± 5.9 | 12.0 ± 4.3 | 0.391 |
C-reactive protein, mg/dL | 3.2 (1.2-12.3) | 2.9 (1.2-13.5) | 3.4 (1.6-9-4) | 0.192 |
pH | 7.376 ± 0.064 | 7.401 ± 0.035 | 7.363 ± 0.078 | 0.286 |
PaO2, mmHg | 63.1 ± 22.7 | 64.6 ± 15.7 | 61.5 ± 17.9 | 0.141 |
PaCO2, mmHg | 47.8 ± 13.3 | 45.5 ± 12.8 | 49.4 ± 17.2 | 0.096 |
MV§ requirements on admission | 9 (3.7) | 8 (6.6) | 1 (4.2) | 0.297 |
Length of stay, days | 9.6 ± 6.4 | 7.5 ± 5.0 | 11.8 ± 9.2 | 0.025 |
30-days follow-up | ||||
Exacerbations, n | 58 (24.1) | 29 (24.1) | 6 (25.0) | 0.540 |
Hospital re-admissions | 34 (14.1) | 17 (14.2) | 3 (12.5) | 0.345 |
Death by any cause | 11 (4.6) | 6 (5.0) | 1 (4.2) | 0.478 |
12-month follow-up | ||||
Exacerbations | 131 (54.5) | 72 (60.0) | 12 (54.4) | 0.299 |
Hospital re-admissions | 93 (38.7) | 52 (43.3) | 7 (31.8) | 0.087 |
ICU admissions | 14 (5.8) | 8 (6.6) | 2 (9.0) | 0.065 |
Death by any cause | 27 (11.3) | 13 (10.8) | 3 (12.5) | 0.373 |