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Figure 4 | Respiratory Research

Figure 4

From: Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

Figure 4

Immunohistochemical analyses. Immunohistochemical analyses for CD45 (green; A, D, and G) and collagen-I (Col-I; red; B, E, and H) staining were performed with lung sections on day 14 of BLM treatment with or without pirfenidone. Merge (yellow; C, F, and I) is co-staining for CD45 and Col-I, indicating bone marrow-derived fibrocytes. Fibrocytes are indicated with arrows. The increased numbers of fibrocytes expressing CD45 and Col-I observed in BLM-treated mice were attenuated by pirfenidone treatment. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole. Original magnification, ×40. PFD, pirfenidone.

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Respiratory Research

ISSN: 1465-993X

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