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Figure 12 | Respiratory Research

Figure 12

From: Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

Figure 12

Pirfenidone regulates chemokine (CC motif) receptor-2 (CCR2) in fibrocytes. Isolated fibrocytes were cultured in the presence or absence of pirfenidone (100 μg/mL) for 48 h. Then, total RNA was extracted and converted to complementary DNA. Quantitative real-time polymerase chain reaction was performed to evaluate CCR2 messenger RNA (mRNA) expression. CCR2 mRNA was significantly attenuated by pirfenidone (*P = 0.0329). Data are means ± standard error from 4 separate experiments, each assayed in triplicate. PFD, pirfenidone.

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