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Table 3 Effects of drugs on cytokine secretion by BE cells from all subjects (mean † , 95% CI, n = 17)

From: Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses

Mock-infected

Drugs

None

Budesonide

Formoterol

Both

CXCL8

3940 (3454, 4426)

3546 (2935, 4157)

4279 (3901, 4657)

3780 (3292, 4268)

CXCL10

7.2 (5.3, 9.8)

2.7 (1.6, 4.6)**

3.8 (2.4, 6.1)**

3.3 (1.8, 5.8)**

TNFα

6.7 (3.9, 11)

0.5 (0.2, 1.4)**

2.4 (0.7, 7.8)*

0.8 (0.2, 2.6)**

RV-infected

    

CXCL8

4163 (3540, 4786)

3504 (2993, 4015)**

4116 (3675, 4557)

3634 (3164, 4104)*

CXCL10

44 (7.0, 249)

29 (9.8, 84)

34 (11, 112)

34 (12, 99)

TNFα

8.1 (4.7, 14)

1.5 (0.5, 4.6)**

2.7 (0.8, 9.2)**

1.3 (0.4, 4.4)**

IFNBI mRNA

2.2 (1.4, 3.2)

2.0 (1.2, 3.8)

2.8 (1.8, 4.3)

2.6 (1.7, 4.0)

IL28 mRNA

32 (14, 74)

19 (8.9, 42)

24 (9.4, 61)

17 (6.7, 42)

  1. †CXCL8 arithmetic mean, others represent geometric means; cytokine protein values represent pg/mL, and mRNA are presented as fold increase after RV infection.
  2. * P ≤ 0.05 drug vs. no drug.
  3. ** P ≤ 0.005 drug vs. no drug.
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Respiratory Research

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