Ceramides: a potential therapeutic target in pulmonary emphysema

Respiratory Research

Table 5 Invasive lung function measurements after Myriocin treatment

Parameter	Unit	Control (n=6)	Control + Myriocin (n=5)	Elastase (n=3)	Elastase + Myriocin (n=3)
Resistance	cmH₂O/mL	0.44 ± 0.03	0.43 ± 0.03	0.37 ± 0.01*	0.41 ± 0.03
Compliance	mL/cmH₂O	0.056 ± 0.005	0.055 ± 0.002	0.082 ± 0.005*	0.063 ± 0.005^#^[]
Airway Resistance	cmH₂O/mL	0.22 ± 0.01	0.22 ± 0.02	0.16 ± 0.03*	0.18 ± 0.01^#
Tissue Elasticity	cmH₂O/mL	17.3 ± 1.5	17.3 ± 0.8	9.9 ± 1.1*	14.0 ± 1.4^{# []}
Total lung capacity	mL	0.93 ± 0.05	0.95 ± 0.03	0.99 ± 0.05	0.93 ± 0.03
Inspiratory Capacity from zero pressure	mL	1.47 ± 0.08	1.49 ± 0.07	1.42 ± 0.06	1.36 ± 0.11
Static Compliance	mL/cmH₂O	0.105 ± 0.006	0.106 ± 0.005	0.104 ± 0.004	0.097 ± 0.009

During invasive lung function measurements, an average for each individual mouse was calculated from 4 accepted (coefficient of determination: COD>0.95) measurements for each parameter. * p<0.05 when compared to Control. ^# p<0.05 when compared to Control + Myriocin. ^[] p<0.05 when compared to Elastase.

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