From: Ceramides: a potential therapeutic target in pulmonary emphysema
Parameter | Unit | Control (n=9) | Elastase (n=10) | Elastase + desimaprimine (n=5) | Elastase + zoledronic acid (n=4) | Elastase + sphingolactone (n=4) |
---|---|---|---|---|---|---|
Resistance (R) | cmH2O/mL | 0.67 ± 0.07 | 0.52 ± 0.03* | 0.47 ± 0.02 * | 0.49 ± 0.01* | 0.54 ± 0.05* |
Compliance (C) | mL/cmH2O | 0.032 ± 0.004 | 0.052 ± 0.004* | 0.066 ± 0.007* | 0.067 ± 0.011* | 0.054 ± 0.007* |
Airway Resistance (Rn) | cmH2O/mL | 0.32 ± 0.03 | 0.23 ± 0.03* | 0.22 ± 0.02* | 0.25 ± 0.01* | 0.21 ± 0.02* |
Tissue Elasticity (H) | cmH2O/mL | 32.4 ± 4.2 | 16.9 ± 2.3* | 13.2 ± 1.3* | 13.9 ± 2.8* | 15.5 ± 2.7* |
Total lung capacity (A) | mL | 0.70 ± 0.05 | 0.78 ± 0.04 | 0.88 ± 0.02 | 0.89 ± 0.07 | 0.77 ± 0.03 |
Inspiratory Capacity (B) from zero pressure | mL | 1.14 ± 0.09 | 1.30 ± 0.11* | 1.47 ± 0.028* | 1.57 ± 0.19* | 1.29 ± 0.09* |
Static Compliance (Cst) | mL/cmH2O | 0.078 ± 0.008 | 0.094 ± 0.009* | 0.108 ± 0.002* | 0.115 ± 0.014* | 0.094 ± 0.008* |