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Table 5 Differential effects of CSD subdomains on monocyte migration, fibrocyte differentiation, and fibroblast collagen and ASMA expression

From: Differential regulation of cell functions by CSD peptide subdomains

Peptide Monoycte migration Fibrocyte differentiation Protein expression in fibroblasts and endothelial cells
Normal TGFβ SSc Normal SSc Collagen NLF Collagen SLF ASMA NLF ASMA SLF eNOS End
Control 20.1 99.9 303 30 54 100 200 100 260  
CSD ↓↓ ↓↓ ↓↓ ↓↓ No Effect ↓↓
Cav-A ↑↑ No Effect No Effect No Effect No Effect No Effect No Effect No Effect
Cav-B Not Done Not Done Not Done No Effect No Effect No Effect No Effect
Cav-C Not Done Not Done Not Done ↓↓ No Effect No Effect
Cav-AB Not Done Not Done Not Done ↓↓ ↓↓ No Effect No Effect
Cav-BC ↓↓ ↓↓ ↓↓ ↓↓ ↓↓
  1. The Control Peptide row shows the baseline values for each cell type for Monocyte Migration (in Cells/hpf from Figure 2 and Table 3), for Fibrocyte Differentiation (in Elongated cells/field from Figure 7), and for Protein Expression in Fibroblasts (in Arbitrary Units from Figure 10). eNOS expression in Endothelial Cell data are from ref. [11]. The other rows show increases and decreases from these baseline levels caused by CSD and related peptides (↑↑ = > 100% increase,  = 35 to 100% increase, No Effect = 35% decrease to 35% increase, ↓ = 35 to 65% decrease, ↓↓ = 65 to 100% decrease.