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Table 4 Differential effects of CSD subdomains on monocyte CXCR4 and F-actin expression

From: Differential regulation of cell functions by CSD peptide subdomains

Cells Peptide CXCR4 Statistical significance F-actin Statistical significance
Normal Control 23.2 ± 0.8   32.1 ± 2.6  
Normal CSD 20.6 ± 1.8   26.8 ± 1.7  
Normal Cav-A 40.6 ± 1.9 p < 0.01 vs Normal/Control 85.8 ± 3.6 p < 0.01 vs Normal/Control
Normal Cav-B 34.6 ± 1.2 p < 0.01 vs Normal/Control 93.9 ± 2.2 p < 0.01 vs Normal/Control
Normal Cav-C 28.7 ± 0.8 p < 0.01 vs Normal/Control 73.7 ± 5.0 p < 0.01 vs Normal/Control
Normal Cav-AB 23.9 ± 0.8   42.0 ± 2.1 p < 0.05 vs Normal/Control
Normal Cav-BC 20.9 ± 0.7   34.5 ± 1.4  
Normal + TGFβ Control 50.1 ± 2.6 p < 0.01 vs Normal/Control 40.7 ± 1.4 p < 0.05 vs Normal/Control
Normal + TGFβ CSD 23.7 ± 0.8 p < 0.01 vs Normal + TGFβ/Control 35.4 ± 2.0 p < 0.05 vs Normal + TGFβ/Control
Normal + TGFβ Cav-A 21.9 ± 0.6 p < 0.01 vs Normal + TGFβ/Control 49.0 ± 3.6  
Normal + TGFβ Cav-B 32.4 ± 1.1 p < 0.01 vs Normal + TGFβ/Control 75.2 ± 3.7 p < 0.01 vs Normal + TGFβ/Control
Normal + TGFβ Cav-C 27.6 ± 0.8 p < 0.01 vs Normal + TGFβ/Control 54.7 ± 4.5 p < 0.01 vs Normal + TGFβ/Control
Normal + TGFβ Cav-AB 22.3 ± 0.6 p < 0.01 vs Normal + TGFβ/Control 47.5 ± 4.7  
Normal + TGFβ Cav-BC 20.4 ± 0.8 p < 0.01 vs Normal + TGFβ/Control 38.7 ± 1.6  
SSc Control 43.8 ± 2.6 p < 0.01 vs Normal/Control 129.2 ± 11.9 p < 0.01 vs Normal/Control
SSc CSD 27.6 ± 1.4 p < 0.01 vs SSc/Control 58.3 ± 2.8 p < 0.01 vs SSc/Control
SSc Cav-A 51.4 ± 2.6   138.1 ± 7.3  
SSc Cav-B 32.6 ± 1.6 p < 0.01 vs SSc/Control 60.9 ± 5.7 p < 0.01 vs SSc/Control
SSc Cav-C 31.5 ± 1.5 p < 0.01 vs SSc/Control 100.0 ± 8.6  
SSc Cav-AB 30.9 ± 2.3 p < 0.01 vs SSc/Control 79.5 ± 5.1 p < 0.01 vs SSc/Control
SSc Cav-BC 27.7 ± 0.8 p < 0.01 vs SSc/Control 92.9 ± 4.5 p < 0.05 vs SSc/Control
  1. Image analyses of Figures 5 and 6 are quantified in terms of average fluorescence intensity ± s.e.m. and the statistical significance of the indicated comparisons determined using Students’ t test.