Figure 7
From: The dopamine D1receptor is expressed and facilitates relaxation in airway smooth muscle
PKA is involved in dopamine D 1 receptor agonist-induced airway smooth muscle relaxation. (A) Representative tension tracing in guinea pig tracheal ring illustrating the effect of pretreatment with the PKA inhibitor Rp-cAMPS (100 μM) or BKCa channel blocker iberiotoxin (100 nM) on relaxation of Ach (EC50) contraction by the dopamine D1-like receptor agonist A68930 (10 - 100 μM). (B) The effect of pretreatment with the PKA inhibitor Rp-cAMPS (100 μM) or BKCa channel blocker iberiotoxin (100 nM) on A68930 (100 μM)-mediated tracheal ring relaxation. Means ± SEM. ***P < 0.001 compared with time control. ##P < 0.01 compared with A68930 alone. N = 6.