| Positive specimen * | Alveolar epithelium | Bronchial epithelium | Adventitia submucosa | Pleura | Blood vessel endothelium |
---|
Control IgG | 3§/19 | 1/19 | 1/15 | 1/15 | 1/18 | 0/18 |
aCEACAM1 | 12/19 | 10/19 | 10/17 | 5/17 | 10/17 | 11/19 |
aCEACAM5 | 18/19 | 16/19 | 17/17 | 11/17 | 12/17 | 15/19 |
aCEACAM6 | 19/19 | 19/19 | 15/18 | 0/18 | 6/18 | 0/19 |
aCEACAM8 | 1§/19 | 1/19 | 0/16 | 0/16 | 1/18 | 0/19 |
- Paraffin sections of human lung tissue from surgical specimens of lung cancer patients (N=19) were stained for CEACAM1, CEACAM5, CEACAM6, CEACAM8 and an unspecific control IgG.
- Figure 1 shows representative pictures of non-cancer tissues for these stainings. CEACAM expression in non-cancer tissues was analyzed for alveolar epithelium, bronchial epithelium, adventitia submucosa, pleura and blood vessel endothelium. Since not all tissue types were found for all specimens, the number of positive specimen and the number of total specimen including the respective tissue are given. *Assessment of total staining includes alveolar epithelium, bronchial epithelium, adventitia submucosa, pleura and blood vessel endothelium and excludes present blood cells due to intrinsic peroxidase activity. §Four lung sections showed enhanced background staining for the control IgG or the anti-CEACAM8 antibody.