Myofibroblast expression in airways and alveoli is affected by smoking and COPD

Respiratory Research

Table 3 Clinical and immunohistochemical correlations in all patients

		Clinical parameters
Immunohistochemical findings	Sex*	Pack-years	FEV₁/FVC	FEV₁	DL_CO
α-SMA in alveoli	p<0.001	ρ=−0.295 p=0.006	ρ=0.426 p<0.001
α-SMA in bronchioles		ρ=−0.241 p=0.027
α-SMA in bronchi	0.05				ρ=0.234 p=0.055
Tn-C in bronchi**	p=0.02	p<0.001
EDA-Fn in alveoli				ρ=−0.210 p=0.047

α-SMA Alpha-smooth muscle actin, Tn-C Tenascin-C, EDA-Fn Extra type III domain A – fibronectin, FEV₁ = Forced expiratory volume in one second, FVC = Forced vital capacity, DL_co = Diffusing capacity of carbon monoxide, ρ Spearman’s rho, *study is not sex-matched, ** Correlations of Tn-C were calculated by ANOVA.

ISSN: 1465-993X