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Table 5 Verification of the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV 1 in sample 2

From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function

  FEV1(ml) b (95% CI)  
Gene Variable In utero ETS Daily ETS Workplace ETS
  N, in analysis 3914 4527 4702
GSTO1 ETS −45 (−91 ; 1) 41 (−78 ; -4)* −40 (−98 ; 18)
  rs4925 11 (−43 ; 65) 15 (−36 ; 66) 33 (−17 ; 83)
  ETS*rs4925 111 (−32 ; 253) 25 (−93 ; 142) −163 (−390 ; 65)
GSTO1 ETS 49 (−96 ; -1)* 40 (−78 ; -2)* −40 (−100 ; 20)
  rs1147611 4 (−40 ; 47) 21 (−21 ; 63) 26 (−15 ; 67)
  ETS*rs1147611 94 (−22 ; 211) 5 (−89 ; 98) −87 (−254 ; 81)
GSTO2 ETS 52 (−99 ; -5)* 41 (−79 ; -4)* −38 (−98 ; 21)
  rs156697 2 (−42 ; 46) 17 (−25 ; 59) 28 (−13 ; 69)
  ETS*rs156697 119 (0 ; 237)* 17 (−79 ; 113) −99 (−269 ; 70)
GSTO2 ETS −46 (−92 ; 1) 40 (−78 ; -3)* −42 (−101 ; 17)
  rs156699 −9 (−58 ; 39) 0 (−46 ; 47) 10 (−35 ; 56)
  ETS*rs156699 106 (−29 ; 241) 9 (−97 ; 115) −101 (−292 ; 91)
  1. Effects for in utero ETS exposure (no/yes), daily ETS exposure (</≥1 hr), workplace ETS exposure (no/yes), the SNPs, and the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV1 in sample 2 (verification). The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked.
  2. *p-value<0.05.