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Table 5 Verification of the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV 1 in sample 2

From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function

 

FEV1(ml) b (95% CI)

 

Gene

Variable

In utero ETS

Daily ETS

Workplace ETS

 

N, in analysis

3914

4527

4702

GSTO1

ETS

−45 (−91 ; 1)

41 (−78 ; -4)*

−40 (−98 ; 18)

 

rs4925

11 (−43 ; 65)

15 (−36 ; 66)

33 (−17 ; 83)

 

ETS*rs4925

111 (−32 ; 253)

25 (−93 ; 142)

−163 (−390 ; 65)

GSTO1

ETS

49 (−96 ; -1)*

40 (−78 ; -2)*

−40 (−100 ; 20)

 

rs1147611

4 (−40 ; 47)

21 (−21 ; 63)

26 (−15 ; 67)

 

ETS*rs1147611

94 (−22 ; 211)

5 (−89 ; 98)

−87 (−254 ; 81)

GSTO2

ETS

52 (−99 ; -5)*

41 (−79 ; -4)*

−38 (−98 ; 21)

 

rs156697

2 (−42 ; 46)

17 (−25 ; 59)

28 (−13 ; 69)

 

ETS*rs156697

119 (0 ; 237)*

17 (−79 ; 113)

−99 (−269 ; 70)

GSTO2

ETS

−46 (−92 ; 1)

40 (−78 ; -3)*

−42 (−101 ; 17)

 

rs156699

−9 (−58 ; 39)

0 (−46 ; 47)

10 (−35 ; 56)

 

ETS*rs156699

106 (−29 ; 241)

9 (−97 ; 115)

−101 (−292 ; 91)

  1. Effects for in utero ETS exposure (no/yes), daily ETS exposure (</≥1 hr), workplace ETS exposure (no/yes), the SNPs, and the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV1 in sample 2 (verification). The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked.
  2. *p-value<0.05.