Table 4 Effects for workplace ETS exposure (n/y), the SNPs, and the interaction of GSTO SNPs (recessive model) with workplace ETS exposure on FEV 1
From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function
| Â | FEV1(ml) b (95% CI) | Â | ||
|---|---|---|---|---|
Gene | Variable | All | Never smokers | Ever smokers |
| Â | N, in analysis | 7149 | 3051 | 4098 |
GSTO1 | Workplace ETS | −26 (−71 ; 20) | −51 (−126 ; 25) | −17 (−73 ; 40) |
|  | rs4925 | 8 (−34 ; 50) | 78 (17 ; 138) | −48 (−105 ; 9) |
|  | ETS*rs4925 | $-173 (−313 ; -33)* | $-281 (−498 ; -64)* | −84 (−268 ; 100) |
GSTO1 | Workplace ETS | −22 (−68 ; 25) | −41 (−117 ; 36) | −15 (−73 ; 43) |
|  | rs1147611 | 8 (−27 ; 42) | 49 (0 ; 99)# | −29 (−78 ; 19) |
|  | ETS*rs1147611 | $-151 (−272 ; -31)* | $-286 (−486 ; -87)** | −65 (−218 ; 87) |
GSTO2 | Workplace ETS | −21 (−67 ; 25) | −41 (−118 ; 36) | −14 (−72 ; 44) |
|  | rs156697 | 8 (−28 ; 44) | 50 (−1 ; 100) | −29 (−79 ; 20) |
|  | ETS*rs156697 | $-170 (−295 ; -46)** | $-287 (−486 ; -88)** | −84 (−245 ; 77) |
GSTO2 | Workplace ETS | −17 (−63 ; 28) | −41 (−117 ; 35) | −9 (−66 ; 48) |
|  | rs156699 | 6 (−32 ; 45) | 43 (−12 ; 98) | −26 (−79 ; 28) |
|  | ETS*rs156699 | $-218 (−349 ; -87)** | $-318 (−525;-111)** | −140 (−311 ; 30) |