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Table 4 Effects for workplace ETS exposure (n/y), the SNPs, and the interaction of GSTO SNPs (recessive model) with workplace ETS exposure on FEV 1

From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function

  FEV1(ml) b (95% CI)  
Gene Variable All Never smokers Ever smokers
  N, in analysis 7149 3051 4098
GSTO1 Workplace ETS −26 (−71 ; 20) −51 (−126 ; 25) −17 (−73 ; 40)
  rs4925 8 (−34 ; 50) 78 (17 ; 138) −48 (−105 ; 9)
  ETS*rs4925 $-173 (−313 ; -33)* $-281 (−498 ; -64)* −84 (−268 ; 100)
GSTO1 Workplace ETS −22 (−68 ; 25) −41 (−117 ; 36) −15 (−73 ; 43)
  rs1147611 8 (−27 ; 42) 49 (0 ; 99)# −29 (−78 ; 19)
  ETS*rs1147611 $-151 (−272 ; -31)* $-286 (−486 ; -87)** −65 (−218 ; 87)
GSTO2 Workplace ETS −21 (−67 ; 25) −41 (−118 ; 36) −14 (−72 ; 44)
  rs156697 8 (−28 ; 44) 50 (−1 ; 100) −29 (−79 ; 20)
  ETS*rs156697 $-170 (−295 ; -46)** $-287 (−486 ; -88)** −84 (−245 ; 77)
GSTO2 Workplace ETS −17 (−63 ; 28) −41 (−117 ; 35) −9 (−66 ; 48)
  rs156699 6 (−32 ; 45) 43 (−12 ; 98) −26 (−79 ; 28)
  ETS*rs156699 $-218 (−349 ; -87)** $-318 (−525;-111)** −140 (−311 ; 30)
  1. The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked. Consequently we stratified by smoking status (never/ever) and adjusted for the other possible confounders.
  2. *p-value<0.05 **p-value<0.01.
  3. $significant after FDR correction for multiple testing.