Table 3 Effects for daily ETS exposure (</≥1 hr), the SNPs, and the interaction of GSTO SNPs (recessive model) with daily ETS exposure on FEV 1
From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function
| Â | FEV1(ml) b (95% CI) | Â | ||
|---|---|---|---|---|
Gene | Variable | All | Never smokers | Ever smokers |
| Â | N, in analysis | 6822 | 2901 | 3921 |
GSTO1 | Daily ETS | −27 (−56;3) | −31 (−79 ; 16) | −28 (−66 ; 10) |
|  | rs4925 | 61 (−37;49) | 67 (6 ; 128)* | −46 (−106 ; 15) |
|  | ETS*rs4925 | −115 (−209;-22)* | −153 (−306 ; 0) | −72 (−192 ; 47) |
GSTO1 | Daily ETS | −25 (−55;5) | −28 (−77 ; 22) | −28 (−67 ; 11) |
|  | rs1147611 | 15 (−22;51) | 56 (5 ; 107)* | −24 (−75 ; 28) |
|  | ETS*rs1147611 | −83 (−159;-7)* | −122 (−247 ; 3) | −45 (−147 ; 52) |
GSTO2 | Daily ETS | −29 (−59;1) | −28 (−77 ; 22) | −34 (−73 ; 5) |
|  | rs156697 | 6 (−31;43) | 57 (5 ; 109)* | −40 (−93 ; 12) |
|  | ETS*rs156697 | −59 (−137;19) | −127 (−252 ; -1)* | −2 (−104 ; 99) |
GSTO2 | Daily ETS | −26 (−56;3) | −29 (−78 ; 19) | −28 (−66 ; 10) |
|  | rs156699 | 6 (−35;46) | 44 (−12 ; 100) | −29 (−86 ; 28) |
|  | ETS*rs156699 | −94 (−178;-10)* | −133 (−268 ; 2) | −56 (−165 ; 54) |