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Table 3 Effects for daily ETS exposure (</≥1 hr), the SNPs, and the interaction of GSTO SNPs (recessive model) with daily ETS exposure on FEV 1

From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function

  FEV1(ml) b (95% CI)  
Gene Variable All Never smokers Ever smokers
  N, in analysis 6822 2901 3921
GSTO1 Daily ETS −27 (−56;3) −31 (−79 ; 16) −28 (−66 ; 10)
  rs4925 61 (−37;49) 67 (6 ; 128)* −46 (−106 ; 15)
  ETS*rs4925 115 (−209;-22)* −153 (−306 ; 0) −72 (−192 ; 47)
GSTO1 Daily ETS −25 (−55;5) −28 (−77 ; 22) −28 (−67 ; 11)
  rs1147611 15 (−22;51) 56 (5 ; 107)* −24 (−75 ; 28)
  ETS*rs1147611 83 (−159;-7)* −122 (−247 ; 3) −45 (−147 ; 52)
GSTO2 Daily ETS −29 (−59;1) −28 (−77 ; 22) −34 (−73 ; 5)
  rs156697 6 (−31;43) 57 (5 ; 109)* −40 (−93 ; 12)
  ETS*rs156697 −59 (−137;19) 127 (−252 ; -1)* −2 (−104 ; 99)
GSTO2 Daily ETS −26 (−56;3) −29 (−78 ; 19) −28 (−66 ; 10)
  rs156699 6 (−35;46) 44 (−12 ; 100) −29 (−86 ; 28)
  ETS*rs156699 94 (−178;-10)* −133 (−268 ; 2) −56 (−165 ; 54)
  1. The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked. Consequently we stratified by smoking status (never/ever) and adjusted for the other possible confounders.
  2. *p-value<0.05.
  3. There were no significant effects after FDR correction for multiple testing.