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Table 2 Effects for in utero ETS exposure (no/yes), the SNPs, and the interaction of GSTO SNPs (recessive model) with in utero ETS exposure on FEV 1

From: GST-omega genes interact with environmental tobacco smoke on adult level of lung function

  FEV1 (ml) b (95% CI)  
Gene Variable All Never smokers Ever smokers
  N, in analysis 6003 2576 3427
GSTO1 In utero ETS −33 (−69 ; 4) −25 (−81 ; 32) −43 (91 ; 5)
  rs4925 −33 (−77 ; 10) −1 (65 ; 63) −58 (−117 ; 1)
  ETS*rs4925 $177 (50 ; 305)** 196 (15 ; 376)* 161 (−18 ; 340)
GSTO1 In utero ETS 40 (−77 ; -2)* −32 (−89 ; 26) 51 (−100 ; -2)*
  rs1147611 −22 (−58 ; 14) 6 (−46 ; 58) −46 (−96 ; 3)
  ETS*rs1147611 $177 (72 ; 283)*** $206 (47 ; 365)* 166 (25 ; 307)*
GSTO2 In utero ETS 41 (−78 ; -3)* −28 (−85 ; 30) 55 (−104 ; -6)*
  rs156697 −28 (−64 ; 9) 9 (−44 ; 62) 59 (−110 ; -8)*
  ETS*rs156697 $198 (90 ; 307)*** 181 (20 ; 342)* $219 (72 ; 366)**
GSTO2 In utero ETS −33 (−70 ; 3) −24 (−81 ; 32) −45 (−93 ; 4)
  rs156699 −30 (−70 ; 10) −9 (−66 ; 49) −48 (−104 ; 7)
  ETS*rs156699 $160 (41 ; 278)** 193 (12 ; 374)* 143 (−15 ; 300)
  1. The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked. Consequently we stratified by smoking status (never/ever) and adjusted for the other possible confounders.
  2. *p-value<0.05 **p-value<0.01 *** p-value<0.001.
  3. $significant after FDR correction for multiple testing.