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Table 1 Concentrations of OVA-specific IgE in the serum

From: Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

  6 hrs (ng/ml) 48 hrs (ng/ml)
PBS/OVA/vehicle/OVA 5.5 ± 10.0 4.7 ± 9.4
OVA/OVA/vehicle/OVA 4682.1 ± 3919.8* 4182.8 ± 2819.6*
OVA/OVA/Sivelestat/OVA 4560.2 ± 2901.4 4855.6 ± 2101.6
  1. Mice were sensitized and challenged as described in Methods. Serum levels of anti-OVA IgE antibody were assessed 6 h and 48 h after the last airway challenge. Mean values±SD are given (n = 8-12 in each group); PBS/OVA/vehicle/OVA: non-sensitized but challenged mice followed by treatment with vehicle; OVA/OVA/vehicle/OVA: sensitized and challenged mice followed by treatment with vehicle; OVA/OVA/Sivelestat/OVA: sensitized and challenged mice followed by treatment with sivelestat. *Significant differences (P<0.05) PBS/OVA/vehicle/OVA and OVA/OVA/vehicle/OVA.