| 6 hrs (ng/ml) | 48 hrs (ng/ml) |
---|
PBS/OVA/vehicle/OVA | 5.5 ± 10.0 | 4.7 ± 9.4 |
OVA/OVA/vehicle/OVA | 4682.1 ± 3919.8* | 4182.8 ± 2819.6* |
OVA/OVA/Sivelestat/OVA | 4560.2 ± 2901.4 | 4855.6 ± 2101.6 |
- Mice were sensitized and challenged as described in Methods. Serum levels of anti-OVA IgE antibody were assessed 6 h and 48 h after the last airway challenge. Mean values±SD are given (n = 8-12 in each group); PBS/OVA/vehicle/OVA: non-sensitized but challenged mice followed by treatment with vehicle; OVA/OVA/vehicle/OVA: sensitized and challenged mice followed by treatment with vehicle; OVA/OVA/Sivelestat/OVA: sensitized and challenged mice followed by treatment with sivelestat. *Significant differences (P<0.05) PBS/OVA/vehicle/OVA and OVA/OVA/vehicle/OVA.