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Figure 1 | Respiratory Research

Figure 1

From: Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

Figure 1

Neutrophil elastase inhibitor attenuates AHR 6 hr after secondary challenge. (A) Changes in RL 6 hr after secondary challenge. RL values to increasing concentrations of inhaled MCh were measured in non-sensitized/OVA-challenged mice receiving saline (PBS/OVA/vehicle/OVA), OVA-sensitized/OVA-challenged mice receiving saline (OVA/OVA/vehicle/OVA), and OVA-sensitized/OVA-challenged mice receiving sivelestat (OVA/OVA/Sivelestat/OVA). Results for each group are expressed as the mean ± SD. (n = 16-24 in each group). (B) Cell composition in BAL fluid obtained 6 hr after secondary challenge. Results for each group are expressed as the mean ± SD. (n = 16 in each group). *Significant differences (P<0.05) between PBS/OVA/OVA/vehicle and OVA/OVA/OVA/vehicle. #Significant differences (P < 0.05) between OVA/OVA/vehicle/OVA and OVA/OVA/Sivelestat/OVA.

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Respiratory Research

ISSN: 1465-993X

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