Table 3 Change in COPD patient characteristics between baseline and year 1 assessment
From: Factors associated with change in exacerbation frequency in COPD
Year 1 Category | Year 1 IE (n=1289) | Year 1 FE (n=543) | ||||
|---|---|---|---|---|---|---|
Year 2 Category | Stayed as IE (n=1068) | Change to FE (n=221) | p-value | Stayed as FE (n=333) | Change to IE (n=210) | p-value |
Change in patient measures (year 1 assessment – baseline) | ||||||
BMI (kg/m2) | 0.0 (1.4) | 0.0 (1.1) | 0.750 | -0.1 (1.4) | -0.1 (1.6) | 0.589 |
FEV1 (mL) | 14 (233) | -46 (184) | <0.001 | -32 (180) | -22 (217) | 0.543 |
FEV1 % predicted | 0.4 (7.7) | -1.6 (6.9) | <0.001 | -1.1 (6.4) | -0.9 (7.8) | 0.690 |
FEV1/FVC % | -0.1 (5.8) | -0.4 (5.2) | 0.534 | -0.3 (6.0) | -0.9 (6.0) | 0.250 |
*Changed smoking status | 6% | 9% | 0.053 | 6% | 9% | 0.153 |
*Re-Started smoking (%) | 5% | 9% | 0.051 | 4% | 4% | 0.726 |
*Stopped smoking (%) | 7% | 10% | 0.448 | 9% | 17% | 0.125 |
6-min walk distance (m) | 10 (90) | -5 (85) | 0.036 | -6 (94) | -1 (84) | 0.568 |
Blood oxygen saturation (%) | 0.0 (2.9) | -0.1 (3.0) | 0.478 | -0.3 (3.3) | -0.2 (2.8) | 0.713 |
mMRC Dyspnoea Score | 0.0 (0.9) | 0.0 (1.0) | 0.682 | 0.1 (1.0) | 0.0 (1.0) | 0.691 |
SGRQ Total Score | --2.0 (10.6) | --1.9 (12.1) | 0.879 | -0.1 (9.9) | -0.1 (10.2) | 0.986 |
BODE Index | 0.0 (1.2) | 0.1 (1.3) | 0.138 | 0.2 (1.5) | 0.1 (1.3) | 0.424 |
White blood cells (10^9/L) | -0.3 (1.6) | -0.2 (1.9) | 0.606 | 0.0 (2.3) | -0.2 (2.1) | 0.289 |
Neutrophils (10^9/L) | -0.2 (1.5) | -0.2 (1.9) | 0.894 | 0.2 (2.3) | -0.1 (2.0) | 0.232 |
Platelets (10^9/L) | -7 (47) | -11 (41) | 0.238 | -5 (51) | -16 (49) | 0.014 |
Fibrinogen (mg/dL) | -6 [-51, 36] | 0 [-38, 41] | 0.151 | 5 [-41,58] | -3 [-52, 38] | 0.109 |
CRP (mg/dL) | 0.1 [-1.3, 1.5] | 0.0 [-1.8, 2.1] | 0.999 | 0.3 [-1.4,3.0] | -0.2 [-2.4, 1.9] | 0.083 |
SP-D (ng/mL) | 0 [-18, 20] | 0 [-23, 26] | 0.654 | -1 [-24, 24] | 0 [-21, 21] | 0.806 |
PARC/CCL-18 (ng/mL) | 6 [-6, 21] | 6 [-9, 23] | 0.628 | 9 [-6, 27] | 6 [-7, 21] | 0.114 |
Change between the number of events in year 1 and in year 2 | ||||||
PPPY COPD Hosp. Year 2 | 0.07 | 0.57 | <0.001 | 0.68 | 0.14 | <0.001 |
PPPY OCS only exbs Y2 | 0.04 | 0.25 | <0.001 | 0.37 | 0.06 | <0.001 |