Table 1 Patient characteristics at the year 1 assessment: data is presented for all patients and sub-divided by exacerbation category in year 1 of follow-up
From: Factors associated with change in exacerbation frequency in COPD
|  | All COPD (n=1832) | FE (n=543) | IE (n=1289) | p-value FE v IE |
|---|---|---|---|---|
Age (years) | 64 (7) | 64 (7) | 64 (7) | 0.751 |
Females (%) | 35% | 41% | 32% | <0.001 |
BMI (kg/m2) | 27 (6) | 26 (6) | 27 (6) | 0.006 |
Active smoker (%) | 36% | 33% | 37% | 0.113 |
*FEV1 (L) | 1.37 (0.55) | 1.14 (0.45) | 1.47 (0.55) | <0.001 |
*FEV1 %predicted | 49 (16) | 43 (16) | 52 (16) | <0.001 |
*FEV1/FVC % | 45 (12) | 41 (12) | 46 (12) | <0.001 |
6-minute walk distance (m) | 385 (123) | 350 (119) | 399 (122) | <0.001 |
%predicted 6MWD | 74 (24) | 69 (23) | 77 (23) | <0.001 |
Blood oxygen saturation (%) | 94.7 (2.9) | 94.2 (3.1) | 94.9 (2.8) | <0.001 |
Emphysema LAA% (-950HU) | 18 (12) | 20 (13) | 17 (12) | <0.001 |
mMRC Dyspnoea Score | 1.7 (1.1) | 2.0 (1.1) | 1.5 (1.0) | <0.001 |
SGRQ-C Total Score | 47 (21) | 57 (18) | 43 (21) | <0.001 |
BODE Index | 3.0 (2.1) | 3.9 (2.2) | 2.7 (2.0) | <0.001 |
White blood cells (10^9/L) | 7.6 (2.2) | 8.1 (2.4) | 7.4 (2.0) | <0.001 |
Platelets (10^9/L) | 266 (71) | 276 (75) | 261 (69) | 0.002 |
Fibrinogen (mg/dL) | 436 [383–504] | 468 [405–535] | 426 [376–492] | <0.001 |
CRP (mg/dL) | 3.3 [1.5-7.3] | 4.1 [1.8-9.1] | 3.1 [1.4-6.6] | <0.001 |
SP-D (ng/mL) | 119 [87–163] | 115 [86–159] | 121 [87–166] | 0.294 |
PARC/CCL-18 (ng/mL) | 112 [87–145] | 119 [92–154] | 111 [85–141] | 0.001 |
Neutrophils (10^9/L) | 5.0 (1.9) | 5.4 (2.2) | 4.8 (1.8) | <0.001 |
Treated with ICSL % | 71% | 81% | 66% | 0.159 |
Treated with LAMA % | 63% | 68% | 60% | <0.001 |
Treated with ICS % | 17% | 15% | 17% | 0.336 |
Treated with LABA % | 14% | 14% | 15% | 0.813 |
Treated with Oxygen % | 10% | 16% | 6% | <0.001 |
PPPY COPD Hosp. Year 1 | 0.20 | 0.55 | 0.05 | <0.001 |
PPPY OCS only exbs Y1 | 0.13 | 0.35 | 0.04 | <0.001 |
Diabetes | 10% | 8% | 10% | 0.287 |
Cardiovascular (excl. HTN) | 33% | 32% | 33% | 0.868 |
Reflux/heartburn | 26% | 33% | 23% | <0.001 |
Anxiety | 16% | 21% | 14% | <0.001 |
Depression symptoms | 25% | 33% | 21% | <0.001 |