Figure 7
From: HTR4 gene structure and altered expression in the developing lung
Regulatory motifs and lung function-associated single nucleotide polymorphisms (SNPs) within the HTR4 gene. HTR4 annotated with RNA sequencing, H3K27Ac histone marks, DNase I hypersensitivity, transcription factor binding, CpG island and placental mammal conservation tracks (UCSC genome browser (http://genome.ucsc.edu/)) on the Human Feb 2009 (GRCh37/hg19) assembly. For the H3K27Ac histone marks and RNA sequence tracks, peak height is proportional to signal amplitude, with colours representing data sets in different cell backgrounds (pale blue H3K27Ac histone trace = human umbilical vein endothelial cell (HUVEC); blue/grey = K562 erythroleukemia cells). For the DNase I hypersensitivity and transcription factor binding tracks, a grey band indicates the extent of the hypersensitive region and the darkness of the band is proportional to the maximum signal strength observed in any cell line. The positions of HTR4 variants in LD (r2>0.80) with the sentinel SNP (rs3995090) identified in the SpiroMeta lung function GWAS [6] are also shown, with the top 2 ranking SNPs (rs3995090 and rs6889822) indicated in red.