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Figure 5 | Respiratory Research

Figure 5

From: The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation

Figure 5

Pro-inflammatory cytokines are elevated in BAL cells and fluids from macrophage-specific PPARγ KO mice 60 days post-instillation of MWCNT. (A) MWCNT instillation of PPARγ KO mice (n=8) significantly increases BAL cell osteopontin mRNA expression compared to sham C57/Bl6 (n=7) or PPARγ KO (n=6) controls. (B). CCL2 mRNA expression is increased in MWCNT-instilled PPARγ KO mice (n=11) compared to sham C57/Bl6 (n=9) or PPARγ KO (n=8) controls. (C) IFNγ mRNA expression is increased in MWCNT-instilled PPARγ KO (n=11) compared to PPARγ KO controls (n=8). BAL fluids from MWCNT-exposed PPARγ KO mice contain elevated: (D) osteopontin compared to sham C57Bl/6 or PPARγ KO controls (n=8/group); and (E) CCL2 (n=6/group) proteins compared to sham controls. CCL2 levels of C57Bl/6 and PPARγ KO sham control groups were below detectable limits of the assay (12.8 pg/ml).

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