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Figure 4 | Respiratory Research

Figure 4

From: The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation

Figure 4

Granulomatous tissues contain elevated pro-inflammatory cytokine expression in macrophage-specific PPARγ KO mice. QPCR of PPARγ KO lung tissues obtained by laser capture microdissection reveal elevated mRNA expression of osteopontin (A) (p = 0.03) and CCL2 (B) (p = 0.04) in granulomatous foci (MWCNT) compared to control wild type lung tissues (n=2/group). Unstained PPARγ KO lung tissue sections (200x) were obtained from control lung (C) or MWCNT-instilled lung (E). Arrows point to MWCNT within granulomas (E). Additional lung tissue sections were stained with antibody to IFN-γ and counterstained with propidium iodide to localize nuclei: (D) Sham control lung; (F) MWCNT-instilled lung. Arrows point to IFN-γ -positive cells within granulomatous foci (F).

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