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Figure 2 | Respiratory Research

Figure 2

From: The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation

Figure 2

Extent of granuloma involvement is greater in PPARγ KO than in wild-type lung tissues. Control lung sections were derived from sham treated wild-type C57/Bl6 (A) and (B) sham treated PPARγ KO mice (200X). (C) Lung sections from C57Bl/6 mice at 60 days after MWCNT instillation show a few aggregates of cells resembling macrophages visible at 100X. (E) At higher power, the aggregates of C57Bl/6 macrophages do not appear to have coalesced into a recognizable granuloma, with the individual cytoplasmic borders of the macrophages easily seen (400X). (D) In contrast, lungs from the PPARγ KO mice demonstrate numerous granulomas containing relatively large aggregates of MWCNT (100X). (F) At higher power, the PPARγ KO macrophages appear to have coalesced into a granuloma, with the syncytial-like loss of cytoplasmic borders characteristic of a well-formed granuloma (400X). (G) Analysis by scoring index indicates increased pulmonary granuloma size (p = 0.01) in PPARγ KO compared to wild-type C57Bl/6 mice (n=6/group).

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