Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study

Kuna, Piotr; Ivanov, Yavor; Trofimov, Vasily Ivanovich; Saito, Takefumi; Beckman, Ola; Bengtsson, Thomas; Jorup, Carin; Maltais, François

doi:10.1186/1465-9921-14-64

Respiratory Research

Table 3 Treatment comparisons for changes from run-in to treatment

From: Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study

	Treatment	Mean change	Treatment contrasts
	Treatment	Mean change		Difference	95% CI	P-value*
CCQ variable
Overall mean	AZD3199 200 μg od	−0.38	AZD3199 200 vs Placebo	−0.262	−0.457, -0.067	0.009
	AZD3199 400 μg od	−0.30	AZD3199 400 vs Placebo	−0.178	−0.369, 0.014	0.068
	AZD3199 800 μg od	−0.36	AZD3199 800 vs Placebo	−0.240	−0.435, -0.045	0.016
	Formoterol 9 μg bid	−0.36	Formoterol 9 vs Placebo	−0.234	−0.427, -0.040	0.018
	Placebo	−0.12	AZD3199 200 vs Formoterol 9	−0.028	−0.219, 0.162	0.770
			AZD3199 400 vs Formoterol 9	0.056	−0.132, 0.243	0.559
			AZD3199 800 vs Formoterol 9	−0.007	−0.198, 0.184	0.945
AZ Diary card COPD Symptoms
Total Score (0–16)	AZD3199 200 μg od	−0.94	AZD3199 200 vs Placebo	−0.480	−1.011, 0.051	0.076
	AZD3199 400 μg od	−0.94	AZD3199 400 vs Placebo	−0.473	−1.000, 0.054	0.078
	AZD3199 800 μg od	−1.19	AZD3199 800 vs Placebo	−0.723	−1.254, -0.192	0.008
	Formoterol 9 μg bid	−0.62	Formoterol 9 vs Placebo	−0.152	−0.685, 0.380	0.574
	Placebo	−0.46	AZD3199 200 vs Formoterol 9	−0.327	−0.852, 0.197	0.220
			AZD3199 400 vs Formoterol 9	−0.321	−0.841, 0.200	0.226
			AZD3199 800 vs Formoterol 9	−0.570	−1.095, -0.046	0.033
SGRQ-C Scores
Total Score	AZD3199 200 μg od	−5.61	AZD3199 200 vs Placebo	−3.01	−7.31, 1.28	0.169
	AZD3199 400 μg od	−8.18	AZD3199 400 vs Placebo	−5.59	−9.78, -1.40	0.009
	AZD3199 800 μg od	−4.63	AZD3199 800 vs Placebo	−2.03	−6.29, 2.23	0.350
	Formoterol 9 μg bid	−4.93	Formoterol 9 vs Placebo	−2.33	−6.65, 1.99	0.289
	Placebo	−2.60	AZD3199 200 vs Formoterol 9	−0.68	−4.89, 3.53	0.751
	Placebo	−2.60	AZD3199 400 vs Formoterol 9	−3.25	−7.34, 0.83	0.118
			AZD3199 800 vs Formoterol 9	0.30	−3.86, 4.47	0.886

*Not adjusted for multiple comparisons.
AZ, AstraZeneca; CCQ, Clinical COPD Questionnaire; SGRQ-C, St George’s Respiratory Questionnaire for COPD.

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