Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study

Kuna, Piotr; Ivanov, Yavor; Trofimov, Vasily Ivanovich; Saito, Takefumi; Beckman, Ola; Bengtsson, Thomas; Jorup, Carin; Maltais, François

doi:10.1186/1465-9921-14-64

Respiratory Research

Table 2 Treatment estimates and pairwise contrasts for FEV ₁ and FVC E _0-4 and E _24-26 , additive model (ml)

From: Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study

	Treatment	Mean change	Treatment contrasts
	Treatment	Mean change		Difference (ml)	95% CI	P-value*
FEV ₁ , E _0–4	AZD3199 200 μg od	199.7	AZD3199 200 vs Placebo	171	69.2, 272.9	0.001
	AZD3199 400 μg od	163.2	AZD3199 400 vs Placebo	135	34.7, 234.3	0.008
	AZD3199 800 μg od	134.3	AZD3199 800 vs Placebo	106	4.6, 206.8	0.041
	Formoterol 9 μg bid	142.8	Formoterol 9 vs Placebo	114	12.8, 215.6	0.027
	Placebo	28.6	AZD3199 200 vs Formoterol 9	57	−42.7, 156.4	0.262
			AZD3199 400 vs Formoterol 9	20	−77.4, 118.2	0.682
			AZD3199 800 vs Formoterol 9	−8	−107.2, 90.3	0.866
FEV ₁ , E _24–26	AZD3199 200 μg od	104.1	AZD3199 200 vs Placebo	99	2.4, 194.9	0.045
	AZD3199 400 μg od	115.9	AZD3199 400 vs Placebo	110	16.0, 204.7	0.022
	AZD3199 800 μg od	102.1	AZD3199 800 vs Placebo	97	0.5, 192.5	0.049
	Formoterol 9 μg bid	23.4	Formoterol 9 vs Placebo	18	−78.0, 113.7	0.714
	Placebo	5.5	AZD3199 200 vs Formoterol 9	81	−13.4, 174.9	0.092
			AZD3199 400 vs Formoterol 9	93	0.1, 185.0	0.050
			AZD3199 800 vs Formoterol 9	79	−15.0, 172.4	0.100
FVC, E _0–4	AZD3199 200 μg od	186.3	AZD3199 200 vs Placebo	192	50.2, 334.3	0.008
	AZD3199 400 μg od	198.2	AZD3199 400 vs Placebo	204	64.9, 343.4	0.004
	AZD3199 800 μg od	146.7	AZD3199 800 vs Placebo	153	11.7, 293.5	0.034
	Formoterol 9 μg bid	162.1	Formoterol 9 vs Placebo	168	26.5, 309.5	0.020
	Placebo	−5.9	AZD3199 200 vs Formoterol 9	24	−114.7, 163.2	0.731
			AZD3199 400 vs Formoterol 9	36	−100.0, 172.3	0.602
			AZD3199 800 vs Formoterol 9	−15	−153.1, 122.3	0.826
FVC, E _24–26	AZD3199 200 μg od	69.8	AZD3199 200 vs Placebo	86	−43.3, 214.9	0.192
	AZD3199 400 μg od	167.9	AZD3199 400 vs Placebo	184	57.4, 310.5	0.005
	AZD3199 800 μg od	97.9	AZD3199 800 vs Placebo	114	−14.7, 242.5	0.082
	Formoterol 9 μg bid	13.5	Formoterol 9 vs Placebo	30	−99.1, 158.1	0.652
	Placebo	−16.0	AZD3199 200 vs Formoterol 9	56	−70.0, 182.6	0.381
	Placebo	−16.0	AZD3199 400 vs Formoterol 9	155	30.7, 278.2	0.015
			AZD3199 800 vs Formoterol 9	84	−41.2, 210.1	0.187

*Not adjusted for multiple comparisons.

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ISSN: 1465-993X

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