Table 3 Hierarchical regression analyses of association of depressive symptoms with pulmonary function, and mediating effect of CRP and IL-6
From: Systemic inflammation, depression and obstructive pulmonary function: a population-based study
Independent | FEV1 % Predicted | FEV1/FVC % Predicted | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Variables | B | SE | β | t | P | B | SE | β | t | P |
Base model | Unadjusted | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 GDS (versus <5) | -4.934 | 2.331 | -0.047 | -2.117 | 0.034 | -4.268 | 2.007 | -0.048 | -2.127 | 0.034 |
 CRP (versus low) | -4.397 | 1.096 | -0.096 | -4.010 | <0.001 | -4.677 | 1.025 | -0.102 | -4.564 | <0.001 |
 IL-6 (versus low) | -5.137 | 1.086 | -0.105 | -4.730 | <0.001 | -4.049 | 1.131 | -0.079 | -3.580 | <0.001 |
Model 1 | Adjusted for smoking, BMI, no. of chronic inflammatory diseases | |||||||||
 GDS (versus <5) | -4.715 | 2.340 | -0.045 | -2.015 | 0.044 | -4.234 | 2.022 | -0.048 | -2.093 | 0.036 |
 CRP (versus low) | -4.239 | 1.131 | -0.092 | -3.747 | <0.001 | -5.013 | 1.059 | -0.109 | -4.732 | <0.001 |
 IL-6 (versus low) | -4.901 | 1.096 | -0.100 | -4.471 | <0.001 | -3.949 | 1.147 | -0.077 | -3.443 | 0.001 |
Model 2 | Adjusted for smoking, BMI, No. of chronic inflammatory diseases, GDS, CRP, and IL-6 | |||||||||
 GDS (versus <5) | -3.895 | 2.332 | -0.040 | -1.670 | 0.095 | -3.760 | 1.940 | -0.044 | -1.938 | 0.053 |
 CRP (versus low) | -3.506 | 1.151 | -0.076 | -3.047 | 0.002 | -3.017 | 0.874 | -0.082 | -3.451 | 0.001 |
 IL-6 (versus low) | -3.584 | 1.164 | -0.075 | -3.079 | 0.002 | -2.708 | 0.890 | -0.071 | -3.043 | 0.002 |