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Table 4 Clinical outcomes (full population)

From: Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH

Outcome

Initial antibiotic treatment modification, n (%), for reasons:*

589 (28.9)

 Insufficient response/treatment failure

244 (12.0)

 Adverse events

41 (2.0)

 Possible interaction with other treatment

1 (<0.1)

 Other

149 (7.3)

 Unknown

47 (2.3)

 No reason reported

107 (5.2)

Death while on initial therapy

63 (3.1)

Streamlining (de-escalation) of therapy, n (%)

105 (5.1)

Time to initial treatment modification, days, mean (SD) [median] (n = 760)

5.0 (3.8) [4.0]

Number of antibiotic therapy courses, n (%)

 

 1

1,086 (53.3)

 2

644 (31.6)

 3

190 (9.3)

 >3

116 (5.7)

Time to clinical stability, days, mean (SD) [median] (n = 1,603)

5.6 (5.1) [4.0]

 Based on Halm criteria (n = 588)

5.3 (5.4) [4.0]

 Based on switch from IV to oral therapy (n = 738)

5.5 (4.1) [5.0]

 Based on other criteria (n = 278)

6.4 (6.6) [5.0]

Length of stay, days, mean (SD) [median] (n = 1,978)

12.6 (10.6) [10.0]

 Patients admitted to the ICU (n = 267)§

19.1 (17.1) [14.0]

 Patients not admitted to the ICU (n = 1,691)§

10.9 (7.5) [9.0]

Discharged from hospital, n (%)

1,836 (90.0)

Reinfection/recurrence, n (%)

94 (4.6)

Home-based care after discharge, n (%)

73 (3.6)

Duration of home-based care, days, mean (SD) [median] (n = 38)

14.7 (15.0) [7.5]

Mortality rate, n (%)

147 (7.2)

  1. * If multiple reasons are reported, the more clinically relevant reasons were selected first as the primary reason for change. The ordering of reasons from most relevant to least relevant are: Adverse event, Insufficient response/treatment failure, Possible interaction with other treatment, Other, Unknown.
  2. De-escalation of treatment to narrower-spectrum antibiotics upon patient improvement or confirmed microbiological diagnosis.
  3. Includes duration of all hospitalizations for patients with recurrences.
  4. § Does not include duration of all hospitalizations for patients with recurrences.
  5. Refers to patients hospitalized again (due to CAP) after initial discharge.
  6. IV: intravenous; SD: standard deviation.