Outcome | |
---|---|
Initial antibiotic treatment modification, n (%), for reasons:* | 589 (28.9) |
Insufficient response/treatment failure | 244 (12.0) |
Adverse events | 41 (2.0) |
Possible interaction with other treatment | 1 (<0.1) |
Other | 149 (7.3) |
Unknown | 47 (2.3) |
No reason reported | 107 (5.2) |
Death while on initial therapy | 63 (3.1) |
Streamlining (de-escalation) of therapy†, n (%) | 105 (5.1) |
Time to initial treatment modification, days, mean (SD) [median] (n = 760) | 5.0 (3.8) [4.0] |
Number of antibiotic therapy courses, n (%) | |
1 | 1,086 (53.3) |
2 | 644 (31.6) |
3 | 190 (9.3) |
>3 | 116 (5.7) |
Time to clinical stability, days, mean (SD) [median] (n = 1,603) | 5.6 (5.1) [4.0] |
Based on Halm criteria (n = 588) | 5.3 (5.4) [4.0] |
Based on switch from IV to oral therapy (n = 738) | 5.5 (4.1) [5.0] |
Based on other criteria (n = 278) | 6.4 (6.6) [5.0] |
Length of stay, days, mean (SD) [median] (n = 1,978)‡ | 12.6 (10.6) [10.0] |
Patients admitted to the ICU (n = 267)§ | 19.1 (17.1) [14.0] |
Patients not admitted to the ICU (n = 1,691)§ | 10.9 (7.5) [9.0] |
Discharged from hospital, n (%) | 1,836 (90.0) |
Reinfection/recurrence, n (%)¶ | 94 (4.6) |
Home-based care after discharge, n (%) | 73 (3.6) |
Duration of home-based care, days, mean (SD) [median] (n = 38) | 14.7 (15.0) [7.5] |
Mortality rate, n (%) | 147 (7.2) |