From: Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
A. Linear regression for FEV1 (L) | ||||||
Exp−856 | E/I MLA | RVC856-950 | ||||
Independent variables | β* | p-value | β* | p-value | β* | p-value |
% emphysema (Insp−950) | −0.11 | < 0.0001 | −0.31 | < 0.0001 | −0.29 | < 0.0001 |
Gas Trapping variable† | −0.45 | < 0.0001 | −0.30 | < 0.0001 | −0.30 | < 0.0001 |
Model fit statistics | ||||||
R2 | 0.67 | 0.68 | 0.68 | |||
B. Linear regression for FEV1/FVC | ||||||
Exp−856 | E/I MLA | RVC856-950 | ||||
Independent variables | β* | p-value | β* | p-value | β* | p-value |
% emphysema (Insp−950) | −0.03 | < 0.0001 | −0.09 | < 0.0001 | −0.10 | < 0.0001 |
Gas Trapping variable† | −0.10 | < 0.0001 | −0.06 | < 0.0001 | −0.03 | < 0.0001 |
Model fit statistics | ||||||
R2 | 0.73 | 0.70 | 0.64 | |||
C. Linear regression for FEF25-75 | ||||||
Exp−856 | E/I MLA | RVC856-950 | ||||
Independent variables | β* | p-value | β* | p-value | β* | p-value |
% emphysema (Insp−950) | 0.0002 | 0.99 | −0.29 | < 0.0001 | −0.38 | < 0.0001 |
Gas Trapping variable† | −0.68 | < 0.0001 | −0.51 | < 0.0001 | −0.24 | < 0.0001 |
Model fit statistics | ||||||
R2 | 0.50 | 0.52 | 0.45 | |||
D. Linear regression for 6-minute walk distance (ft). | ||||||
Exp−856 | E/I MLA | RVC856-950 | ||||
Independent variables | β* | p-value | β* | p-value | β* | p-value |
% emphysema (Insp−950) | −47.8 | < 0.0001 | −46.3 | < 0.0001 | −37.3 | < 0.0001 |
Gas Trapping variable† | −3.7 | 0.6 | −22.0 | < 0.0001 | −51.8 | < 0.0001 |
Model fit statistics | ||||||
R2 | 0.44 | 0.44 | 0.45 | |||
E. Linear regression for SGRQ Total score. | ||||||
Exp−856 | E/I MLA | RVC856-950 | ||||
Independent variables | β* | p-value | β* | p-value | β* | p-value |
% emphysema (Insp−950) | 1.3 | 0.0004 | 2.8 | < 0.0001 | 2.7 | < 0.0001 |
Gas Trapping variable† | 3.2 | < 0.0001 | 1.9 | < 0.0001 | 1.7 | < 0.0001 |
Model fit statistics | ||||||
R2 | 0.42 | 0.42 | 0.42 |