Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

Respiratory Research

Table 1 Characteristics of BAL subjects used for RNA studies

Group	Smokers	Never-smokers	pvalue
Subjects, n	11	6
Sex ratio, M/F	11/0	2/4	0.003
Age, years (SD)	65.5 (7.2)	37.7 (12)	0.002
Smoking, pack-years (SD)	65.5 (23.1)	0 (0)	0.0008
Smoking status (Former/Current)	2/9	0/0	0.003
FEV₁, % pred. (SD)	57 (22.1)	101 (8.7)	0.002
FEV1/FVC% (SD)	58.5 (15.6)	86.8 (4.9)	0.0007
ICS use (yes/no)	7/4	0/6	0.02

ICS Inhaled Corticosteroid Use, M Male, F Female. Data are represented as mean (SD), ratio of current smokers to former smokers, or fraction of ICS users (yes/no). All FEV1 values are pre-bronchodilator. p values calculated using Mann Whitney test.

ISSN: 1465-993X