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Figure 3 | Respiratory Research

Figure 3

From: Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia

Figure 3

Role of MIF in the mouse BPD model: impact on mRNA expression of vascular factors and their receptors. NB MIF KO, MIF TG and WT control mice were exposed to 100% O2 for PN1-4, with recovery in RA from PN5-14 (BPD model). The mice were sacrificed at PN14. The ratios of mRNA of VEGF -A, -C and their receptors -R1 and -R3 (3A and 3B) as well as Ang1 and Ang2 and their receptor Tie2 (3C) with β-actin were quantified by densitometry. The noted values represent assessments in a minimum of 7 animals in each group. The figure is representative of n=3-4 mice per group. MIF +/+: wild type; MIF −/−: macrophage migration inhibitory factor knock out; MIF TG +: macrophage migration inhibitory factor (over-expressing) transgenic; BPD: bronchopulmonary dysplasia mouse model. VEGF: vascular endothelial growth factor; R: receptor; Ang: angiopoietin; β-actin: beta-actin. ##P<0.0001, #P≤0.01, *P<0.05.

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