Variables

Baseline 6MWD

pvalue

Final 6MWD

pvalue


Coefficient (95% CI)

Coefficient (95% CI)


Gender (Male)

48.36 (8.61, 88.10)

0.02

22.64 (−26.55, 71.84)

0.35

Age (years)

−1.40 (−4.77, 1.96)

0.40

−0.60 (−4.88, 3.66)

0.77

FEV_{1} (%)

1.57 (0.74, 2.40)

<0.001

1.88 (0.82, 2.95)

<0.001

IL6 (pg/ml)

−42.02 (−65.49, 22.56)

<0.001

−54.86 (−82.40, 27.32)

<0.001

Charlson index

−8.81 (−33.77, 16.18)

0.48

−11.52 (−43.31, 20.25)

0.46

 Baseline (R^{2} = 0.52; p ≤ 0.05) and after three years (R^{2} = 0.44; p ≤ 0.05). Definition of abbreviations: 6MWD = sixminute walking distance; FEV_{1} = forced expiratory volume in the first second (% of predicted); IL6 = Interleukin 6. For both regression analysis the variables values were those obtained at baseline.