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Table 3 Changes in pulmonary function, 6-minute walk test, and health-related quality of life before and after 12 weeks of pulmonary rehabilitation in patients with interstitial lung disease vs. chest Wall disease

From: Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlled study

 

Non-NPV-exercise group

NPV-exercise group

Baseline

12 weeks

Baseline

12 weeks

FVC, % predicted

    

 ILD

40.3 ± 10.3

38.4 ± 13.5

36.3 ± 13.0

40.5 ± 11.6b, c

 Chest wall

32.7 ± 8.6

37.0 ± 14.5

28.0 ± 8.5

28.3 ± 7.4

FEV1, % predicted

    

 ILD

45.6 ± 11.8

43.8 ± 18.2

40.9 ± 15.8

45.9 ± 15.2a

 Chest wall

35.3 ±11.3

44.2 ± 20.2

31.9 ± 8.6

33.3 ± 8.0

FEV1/FVC, %

    

 ILD

81.8 ± 6.8

84.4 ±7.9

82.3 ± 9.7

81.0 ±11.8

 Chest wall

88.8 ± 10.6

82.2 ± 8.1

83.8 ± 9.7

86.6 ± 9.1

6MWD, m

    

 ILD

385.2 ± 82.6

355.3 ± 85.0

352.3 ± 52.8

399.5 ± 45.1a

 Chest wall

318.2 ± 122.4

288.0 ± 99.3

395.0 ± 99.9

412.8 ± 109.8

SaO2, % pre/post 6MWT

    

 ILD

94.3/ 78.7

93.1/ 78.6

96.0/80.5

96.3/83.1

 Chest wall

94.8/ 77.3

93.3/ 73.3

91.3/72.6

92.4/74.1

Borg, pre/ post 6MWT

    

 ILD

0.9/ 5.1

1.5/5.8

1.7/ 5.5

0.8/4.8

 Chest wall

2.0/ 5.8

1.7/5.8

1.1/ 5.3

0.8/5.0

SGRQ

    

 Symptom score

    

  ILD

47.6 ± 21.5c

42.1 ± 19.3c

61.7 ± 16.6e

29.5 ± 19b,e

  Chest wall

50.3 ± 5.8d

64.1 ± 0.2d

53.7 ± 5.8f

45.9 ± 5.6a,f

 Active score

    

  ILD

62.2 ± 21.5

73.7 ± 12.8

61.4 ± 27.4

53.5 ± 23.2

  Chest wall

59.5 ± 0.0

66.4 ± 18.8

43.9 ± 17.6

36.5 ± 22.0

 Impacts score

    

  ILD

29.3 ± 13.6

43.9 ± 19.2

48.3 ± 25.3

30.0 ± 25.3a

  Chest wall

32.9 ± 16.7

58.0 ± 38.9

21.2 ± 11.7

13.5 ± 12.2

 Total score

    

  ILD

42.3 ± 16.0

52.6 ± 14.0

54.5 ± 21.3

37.0 ± 21.1a

  Chest wall

43.8 ± 9.8

61.6 ± 26.4

32.2 ± 10.0

21.3 ± 11.5a

  1. Values are mean ± SD.
  2. a p < 0.05, baseline vs. 12 weeks; b p < 0.01, baseline vs. 12 weeks; cn = 8; dn = 2; en = 10; fn = 8.