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Table 2 Changes in pulmonary function, 6-minute walk test, and health-related quality of life before and after 12 weeks of pulmonary rehabilitation

From: Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlled study

 

Non-NPV-exercise group

NPV-exercise group

Baseline

12 weeks

Baseline

12 weeks

(n = 18)

(n = 18)

(n = 18)

(n = 18)

FVC, % predicted

37.7 ± 2.4

37.9 ± 3.2

32.6 ± 2.8

35.1 ± 2.7a

FEV1, % predicted

42.2 ± 2.9

43.9 ± 4.3

36.9 ± 3.2

40.3 ± 3.3a

FEV1/FVC, %

84.1 ± 8.6

83.6 ± 7.8

82.9 ± 9.4

83.5 ± 10.8

6MWD, m

362.8 ± 99.4

330.3 ± 94.4

371.3 ± 77.9

405.4 ± 78.1a

SaO2, % pre/post 6MWT

94.0/ 81.4

93.2/ 76.8

93.9/ 77.0

94.6/ 79.1

HR, pre/ post 6MWT

98.2/ 125.8

101.4/ 127.7

103.3/ 126.7

92.0/ 123.4

Borg, pre/ post 6MWT

0.5/ 5.0

1.5/ 7.0

1.25/ 5.0

0/ 4.5a

 (range)

(0–4)/ (3–10)

(0–4)/ (2–9)

(0–4)/ (4–8)

(0–4)/ (1–8)

Limb muscle power

    

 R-upper limb, lb

32.9 ± 1.8b

32.3 ± 1.6b

31.0 ± 2.1c

33.5 ± 2.2a, c

 L-upper limb, lb

30.2 ± 3.5b

33.0 ± 4.7b

29.6 ± 1.6c

30.3 ± 1.6c

 R-low limb, lb

44.3 ± 3.9b

46.2 ± 4.9b

38.5 ± 3.0c

41.4 ± 2.3c

 L-low limb. lb

41.2 ± 3.4b

41.3 ± 4.6b

38.2 ± 2.7c

40.7 ± 2.2c

SGRQ

    

 Symptom score

48.2 ± 6.0e

46.5 ± 6.1e

54.6 ± 5.0

24.5 ± 4.0a

 Active score

61.6 ± 6.0e

72.3 ± 6.1e

53.7 ± 5.8

45.9 ± 5.6a

 Impacts score

30.0 ± 4.2e

46.7 ± 7.0a,e

36.2 ± 5.7

22.6 ± 5.1a

 Total score

42.6 ± 4.6e

54.4 ± 4.9e

44.6 ± 4.8

30.0 ± 4.4a

  1. Values are mean ± SD.
  2. a p < 0.05, baseline vs. 12 weeks.
  3. b only 6 patients in the non-NPV exercise group received limb muscle tests.
  4. c 17 patients in the NPV exercise group received limb muscle tests.
  5. e only 10 patients in the non-NPV exercise group completed the SGRQ at 12 weeks.