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Figure 3 | Respiratory Research

Figure 3

From: Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

Figure 3

Collagen synthesis is enhanced by TGF-β 1 in control and COPD fibroblasts and attenuated by iloprost treatment. Collagen I production was measured as the propeptide of type I procollagen (PINP) in the supernatant from distal lung fibroblasts from control subjects (n = 5; A) and patients with COPD (n = 7; B). Cells were stimulated with iloprost (1000 nM) and TGF-β1 (10 ng/ml) in 0.4% fibroblast medium pretreated with indomethacin (3 μM). Data are presented as median with individual values and median values are represented as a line. *p < 0.05. Statistical analysis is performed with Mann Whitney t-test to compare differences between control and COPD fibroblasts and Wilcoxon paired rank sum test is used to analyze differences within the control and COPD fibroblasts.

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