Figure 2
From: Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts
A. Prostacyclin production is increased in COPD fibroblasts after TGF-β 1 stimulation. Prostacyclin synthesis was measured as 6-keto PGF1α in the supernatant from distal lung fibroblasts from control subjects (n = 9) and patients with COPD (n = 7). Cells were stimulated with TGF-β1 (10 ng/ml) in 0.4% fibroblast medium. Data are presented as median with individual values and median values are represented as a line. *p < 0.05, **p < 0.01. Statistical analysis is performed with Mann Whitney test to compare differences between control and COPD fibroblasts and Wilcoxon paired rank sum test is used to analyze differences within the control and COPD fibroblasts after TGF-β1 stimulation. B. There is no difference in endogenous TGF-β1 production in control or COPD fibroblasts. TGF-β1 production measured in supernatant from distal lung fibroblasts from control subjects (n = 9) and patients with COPD (n = 7). Data are presented as median with individual values and median values are represented as a line. Statistical analysis is performed with Mann Whitney test to compare differences between control and COPD fibroblasts.